abstract：OBJECTIVE:C-C chemokine receptor type 5 (CCR5) has been implicated in rheumatoid arthritis and several inflammatory diseases, where its blockade resulted in reduced joint destruction. However, its role in modulating cartilage and bone changes in post-traumatic osteoarthritis (OA) has not yet been investigated. In this ...

journal_title：Osteoarthritis and cartilage

authors： Takebe K,Rai MF,Schmidt EJ,Sandell LJ

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the thickness of cartilage at the posterior aspect of the medial and lateral condyle in Osteoarthritis (OA) knees compared to non-OA knees using computed tomography arthrography (CTA). DESIGN:535 consecutive knee CTAs (mean patient age = 48.7 ± 16.0; 286 males), were retrospectively analyzed. Kne...

journal_title：Osteoarthritis and cartilage

authors： Omoumi P,Michoux N,Roemer FW,Thienpont E,Vande Berg BC

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of a single intra-articular (IA) dose of FX006, an extended-release formulation of triamcinolone acetonide (TCA) in poly(lactic-co-glycolic acid) (PLGA) microspheres, on the sequelae of repeated episodes of synovitis. DESIGN:Three flares of localized synovitis in the right knee of ra...

journal_title：Osteoarthritis and cartilage

authors： Kumar A,Bendele AM,Blanks RC,Bodick N

更新日期：2015-01-01 00:00:00

abstract：:Despite promising results, the U.S. Food and Drug Administration (FDA) put on hold trials assessing anti-nerve growth factor (a-NGF) compounds due to concerns over accelerated rates of OA progression. The mechanism of these events is unclear but joint adverse events were observed particularly in patients using a-NGFs ...

journal_title：Osteoarthritis and cartilage

authors： Roemer FW,Hayes CW,Miller CG,Hoover K,Guermazi A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Study the impact of intra-articular interleukin-1 receptor antagonist (IL-1 ra) treatment on lubricin biosynthesis following anterior cruciate ligament transection (ACLT) in the rat and evaluate the effect of combined IL-1 ra and recombinant human lubricin (rhPRG4) treatments on chondrocyte apoptosis. METHOD...

journal_title：Osteoarthritis and cartilage

authors： Elsaid KA,Zhang L,Shaman Z,Patel C,Schmidt TA,Jay GD

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To compare the 2D and 3D MOCART system obtained with 9.4 T high-field magnetic resonance imaging (MRI) for the ex vivo analysis of osteochondral repair in a translational model and to correlate the data with semiquantitative histological analysis. METHODS:Osteochondral samples representing all levels of repa...

journal_title：Osteoarthritis and cartilage

authors： Goebel L,Zurakowski D,Müller A,Pape D,Cucchiarini M,Madry H

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The quantitative interpretation of hip cartilage magnetic resonance imaging (MRI) has been limited by the difficulty of identifying and delineating the cartilage in a three-dimensional (3D) dataset, thereby reducing its routine usage. In this paper a solution is suggested by unfolding the cartilage to planar ...

journal_title：Osteoarthritis and cartilage

authors： Siversson C,Akhondi-Asl A,Bixby S,Kim YJ,Warfield SK

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Sensitive biomarkers are needed to understand synovial response to therapy in osteoarthritis (OA). Dynamic, contrast-enhanced magnetic resonance imaging (DCE MRI) provides quantitative, novel measures of synovial inflammation. This exploratory study examined DCE-assessed synovial response to intra-articular c...

journal_title：Osteoarthritis and cartilage

authors： Wenham CY,Balamoody S,Grainger AJ,Hensor EM,Draycott S,Hodgson R,Conaghan PG

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:This systematic literature review aimed to evaluate the use of conventional radiography (CR) in hand osteoarthritis (OA) and to assess the metric properties of the different radiographic scoring methods. DESIGN:Medical literature databases up to November 2013 were systematically reviewed for studies reportin...

journal_title：Osteoarthritis and cartilage

authors： Visser AW,Bøyesen P,Haugen IK,Schoones JW,van der Heijde DM,Rosendaal FR,Kloppenburg M

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To date, no approved clinical intervention successfully prevents the progressive degradation of injured articular cartilage that leads to osteoarthritis (OA). Stem/progenitor cell populations within tissues of diarthrodial joint have shown their therapeutic potential in treating OA. However, this potential ha...

journal_title：Osteoarthritis and cartilage

authors： Yu Y,Zheng H,Buckwalter JA,Martin JA

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To examine the association between sedentary behavior and blood pressure (BP) among Osteoarthritis Initiative (OAI) participants. DESIGN:We conducted a cross-sectional analysis of the OAI 48-month visit participants whose physical activity was measured using accelerometers. Participants were classified into ...

journal_title：Osteoarthritis and cartilage

authors： Sohn MW,Manheim LM,Chang RW,Greenland P,Hochberg MC,Nevitt MC,Semanik PA,Dunlop DD

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To validate an automatic scheme for the segmentation and quantitative analysis of the medial meniscus (MM) and lateral meniscus (LM) in magnetic resonance (MR) images of the knee. METHOD:We analysed sagittal water-excited double-echo steady-state MR images of the knee from a subset of the Osteoarthritis Init...

journal_title：Osteoarthritis and cartilage

authors： Paproki A,Engstrom C,Chandra SS,Neubert A,Fripp J,Crozier S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies have shown an association between increased bone mineral density (BMD) and osteoarthritis (OA), but whether this represents cause or effect remains unclear. In this study, we used a novel approach to investigate this question, determining whether individuals with High Bone Mass (HBM) h...

journal_title：Osteoarthritis and cartilage

authors： Hardcastle SA,Dieppe P,Gregson CL,Hunter D,Thomas GE,Arden NK,Spector TD,Hart DJ,Laugharne MJ,Clague GA,Edwards MH,Dennison EM,Cooper C,Williams M,Davey Smith G,Tobias JH

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA). However, OA synovial fluid and factors secreted by synovium impede chondrogenic differentiation of MSCs, and the mechanism responsible for this effect remains unclear. In this study, we sought t...

journal_title：Osteoarthritis and cartilage

authors： Fahy N,de Vries-van Melle ML,Lehmann J,Wei W,Grotenhuis N,Farrell E,van der Kraan PM,Murphy JM,Bastiaansen-Jenniskens YM,van Osch GJ

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:To investigate the role of Vhl in maintaining the integrity of articular cartilage and in the development of experimental osteoarthritis (OA). METHOD:Histology of articular cartilage and subchondral bone in both Vhl cKO and WT mice were analyzed by histopathology and micro-CT. Articular cartilage destruction...

journal_title：Osteoarthritis and cartilage

authors： Weng T,Xie Y,Yi L,Huang J,Luo F,Du X,Chen L,Liu C,Chen D,Chen L

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the effects of low-magnitude high-frequency vibration (LMHFV) on degenerated articular cartilage and subchondral bone in anterior cruciate ligament transection (ACLT) induced osteoarthritis (OA) rat model. METHODS:6 months old female Sprague-Dawley rats received ACLT on right knee and randomly d...

journal_title：Osteoarthritis and cartilage

authors： Qin J,Chow SK,Guo A,Wong WN,Leung KS,Cheung WH

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:To examine the feasibility of a 10-week gait modification program in people with medial tibiofemoral knee osteoarthritis (OA), and to assess changes in clinical and biomechanical outcomes. DESIGN:Fifteen people with medial knee OA completed 10 weeks of gait modification focusing on increasing toe-out angle d...

journal_title：Osteoarthritis and cartilage

authors： Hunt MA,Takacs J

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Ankle fracture patients were used as a model to study the long-term effect of the removal of joint loading on knee cartilage quality in human subjects. DESIGN:The knees of 10 patients with ipsilateral ankle fractures were investigated using delayed gadolinium-enhanced magnetic resonance imaging of cartilage ...

journal_title：Osteoarthritis and cartilage

authors： Owman H,Tiderius CJ,Ericsson YB,Dahlberg LE

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the site-dependent changes in the structure and function of articular cartilage in the lapine knee joint at a very early stage of osteoarthritis (OA), created experimentally by anterior cruciate ligament transection (ACLT). METHODS:Unilateral ACLT was performed in eig...

journal_title：Osteoarthritis and cartilage

authors： Mäkelä JT,Rezaeian ZS,Mikkonen S,Madden R,Han SK,Jurvelin JS,Herzog W,Korhonen RK

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of intra-articular hyaluronic acid (IAHA) injection in knee joints of patients with Kashin-Beck disease (KBD). METHODS:We searched nine electronic databases as well as unpublished data from inception until November 30th 2013 using a combination of search terms for KBD and hy...

journal_title：Osteoarthritis and cartilage

authors： Yu FF,Xia CT,Fang H,Han J,Younus MI,Guo X

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To compare measurement properties of the P4 pain scale, Western Ontario and McMaster Universities Arthritis Index pain subscale (WOMAC-pain), and Intermittent and Constant Osteoarthritis Pain (ICOAP) measure in patients with knee osteoarthritis (OA). DESIGN:A secondary analysis from a randomized controlled t...

journal_title：Osteoarthritis and cartilage

authors： Robbins SM,Rastogi R,Howard J,Rosedale R

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To develop a whole joint scoring system, the Anterior Cruciate Ligament OsteoArthritis Score (ACLOAS), for magnetic resonance imaging (MRI)-based assessment of acute anterior cruciate ligament (ACL) injury and follow-up of structural sequelae, and to assess its reliability. DESIGN:Baseline and follow-up 1.5 ...

journal_title：Osteoarthritis and cartilage

authors： Roemer FW,Frobell R,Lohmander LS,Niu J,Guermazi A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVES:We hypothesized that high-molecular-weight (MW) cross-linked (CL) hyaluronic acid (HA) improves joint lubrication and has an enhanced chondroprotective effect. We examined the histopathological changes and friction coefficients in osteoarthritic knee joints after injecting high-MW CL HA. DESIGN:A bilateral ...

journal_title：Osteoarthritis and cartilage

authors： Elmorsy S,Funakoshi T,Sasazawa F,Todoh M,Tadano S,Iwasaki N

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To systematically appraise the evidence on measurement properties of performance-based outcome measures to assess physical function in young and middle-aged people known to be at high risk of hip and/or knee osteoarthritis (OA). METHODS:Electronic searches were performed in MEDLINE, CINAHL, Scopus and SPORT...

journal_title：Osteoarthritis and cartilage

authors： Kroman SL,Roos EM,Bennell KL,Hinman RS,Dobson F

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To study the effect of intra-articular injection of meloxicam (Mobic) on the development of osteoarthritis (OA) in rats and examine concomitant changes in nociceptive behavior and the expression of mitogen-activated protein kinases (MAPKs) in articular cartilage chondrocytes. METHODS:OA was induced in Wistar...

journal_title：Osteoarthritis and cartilage

authors： Wen ZH,Tang CC,Chang YC,Huang SY,Chen CH,Wu SC,Hsieh SP,Hsieh CS,Wang KY,Lin SY,Lee HL,Lee CH,Kuo HC,Chen WF,Jean YH

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To determine whether autophagy contributes to the pathogenesis of degenerative disc disease (DDD) or retards the intervertebral disc (IVD) degeneration, and investigate the possible relationship between compression-induced autophagy and intracellular reactive oxygen species (ROS) in nucleus pulposus (NP) cell...

journal_title：Osteoarthritis and cartilage

authors： Ma KG,Shao ZW,Yang SH,Wang J,Wang BC,Xiong LM,Wu Q,Chen SF

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:Marked differences exist between human knee and ankle joints regarding risks and progression of osteoarthritis (OA). Pathomechanisms of degenerative joint disease may therefore differ in these joints, due to differences in tissue structure and function. Focusing on structural issues, which are design goals fo...

journal_title：Osteoarthritis and cartilage

authors： Quinn TM,Häuselmann HJ,Shintani N,Hunziker EB

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:When chondrocytes prepared from cartilage are expanded in monolayer culture, fibroblast-like cells gradually prevail. Although these prevailing fibroblast-like cells are believed to emerge because of the dedifferentiation of chondrocytes, the definite origin of the prevailing fibroblast-like cells has not bee...

journal_title：Osteoarthritis and cartilage

authors： Minegishi Y,Hosokawa K,Tsumaki N

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To establish an in vivo, normative patellofemoral (PF) cartilage contact mechanics database acquired during voluntary muscle control using a novel, dynamic, magnetic resonance (MR) imaging-based, computational methodology and validate the contact mechanics sensitivity to the known sub-millimeter methodologic...

journal_title：Osteoarthritis and cartilage

authors： Borotikar BS,Sheehan FT

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To study the effect of 17β-estradiol (E2) and the superficial zone (SFZ) on cell death and proteoglycan degradation in articular cartilage after a single injurious compression in vitro. METHOD:Cartilage explants from the femoropatellar groove of 2 year old cows with or without the SFZ were cultured serum-fre...

journal_title：Osteoarthritis and cartilage

authors： Imgenberg J,Rolauffs B,Grodzinsky AJ,Schünke M,Kurz B

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:Varus thrust visualized during walking is associated with a greater medial knee load and an increased risk of medial knee osteoarthritis (OA) progression. Little is known about how varus thrust presence determined by visual observation relates to quantitative gait kinematic data. We hypothesized that varus th...

journal_title：Osteoarthritis and cartilage

authors： Chang AH,Chmiel JS,Moisio KC,Almagor O,Zhang Y,Cahue S,Sharma L

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To evaluate ankle joint abnormalities in a knee osteoarthritis (OA) cohort. METHODS:Participants (n = 159) with symptomatic and radiographic OA in at least one knee underwent technetium-99m methylene diphosphonate bone scan (scored 0-3) of the ankles and forefeet. Knee radiographs were graded for OA features...

journal_title：Osteoarthritis and cartilage

authors： Kraus VB,Worrell TW,Renner JB,Coleman RE,Pieper CF

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To identify the effect of alterations in physical parameters such as oxygen and pH on processes associated with cellular redox balance in osteoarthritic chondrocytes. METHOD:Human osteoarthritic chondrocytes (HOAC) were isolated from total knee arthroplasty samples and cultured in 3-D alginate beads in four ...

journal_title：Osteoarthritis and cartilage

authors： Collins JA,Moots RJ,Winstanley R,Clegg PD,Milner PI

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To compare the population prevalence, inter-relationships, risk factor profiles and clinical characteristics of subsets of symptomatic hand osteoarthritis (OA) with a view to understanding their relative frequency and distinctiveness. METHOD:1076 community-dwelling adults with hand symptoms (60% women, mean ...

journal_title：Osteoarthritis and cartilage

authors： Marshall M,Peat G,Nicholls E,van der Windt D,Myers H,Dziedzic K

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors. DESIGN:The study population is part of the Rotterdam Study, a prospective population-based cohort. Baseline pelvic radiographs were used to measure hip geome...

journal_title：Osteoarthritis and cartilage

authors： Castaño-Betancourt MC,Van Meurs JB,Bierma-Zeinstra S,Rivadeneira F,Hofman A,Weinans H,Uitterlinden AG,Waarsing JH

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Previous longitudinal studies have shown no associations between increasing amount of radiographic hand osteoarthritis (OA) and levels of hand pain/disability. In this longitudinal study, we aimed to study whether radiographic hand OA was related to pain/disability in cross-sectional and longitudinal settings...

journal_title：Osteoarthritis and cartilage

authors： Haugen IK,Slatkowsky-Christensen B,Bøyesen P,van der Heijde D,Kvien TK

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is a debilitating chronic condition requiring long-term treatment of pain and functional impairment. Our objective was to characterize studies addressing management of OA-related pain with respect to the breadth of interventions, trial duration and size, outcome measures, and funding sourc...

journal_title：Osteoarthritis and cartilage

authors： Losina E,Dervan EE,Daigle ME,Katz JN

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:The major complaint of Osteoarthritis (OA) patients is pain. However, due to the nature of clinical studies and the limitation of animal studies, few studies have linked function impairment and behavioral changes in OA animal models to cartilage loss and histopathology. Our objective was to study surrogate ma...

journal_title：Osteoarthritis and cartilage

authors： Ruan MZ,Patel RM,Dawson BC,Jiang MM,Lee BH

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Current histological scoring methods to evaluate efficacy of potential therapeutics for slowing or preventing joint degeneration are time-consuming and semi-quantitative in nature. Hence, there is a need to develop and standardize quantitative outcome measures to define sensitive metrics for studying potentia...

journal_title：Osteoarthritis and cartilage

authors： Thote T,Lin AS,Raji Y,Moran S,Stevens HY,Hart M,Kamath RV,Guldberg RE,Willett NJ

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the early repair response of cartilage defects in trochlea (TR) and medial femoral condyle (MFC) at 2-3 weeks after bone marrow stimulation. DESIGN:Bilateral full-thickness cartilage defects were generated in central trochlear groove and MFC of skeletally mature rabbits. ...

journal_title：Osteoarthritis and cartilage

authors： Chen H,Chevrier A,Hoemann CD,Sun J,Lascau-Coman V,Buschmann MD

更新日期：2013-07-01 00:00:00